{"id":8807,"date":"2026-02-20T07:18:03","date_gmt":"2026-02-20T12:18:03","guid":{"rendered":"https:\/\/www.airseadg.com\/en-us\/?p=8807"},"modified":"2026-08-06T06:47:40","modified_gmt":"2026-08-06T10:47:40","slug":"what-are-the-key-packaging-requirements-for-un3373-substances-under-pi-650","status":"publish","type":"post","link":"https:\/\/www.airseadg.com\/en-us\/packaging-guidance\/what-are-the-key-packaging-requirements-for-un3373-substances-under-pi-650\/","title":{"rendered":"What Are the Key Packaging Requirements for UN3373 Substances Under PI 650?"},"content":{"rendered":"<h2>Do you ship UN3373?<\/h2>\n<p>If your organization ships <strong>UN3373 Biological Substance, Category B<\/strong> materials in the United States, understanding the legal packaging requirements is essential. Below is a summary guide to the key requirements under <strong>Packing Instruction PI 650 and CFR173.199<\/strong>.<\/p>\n<p>For companies looking to purchase <a href=\"https:\/\/www.airseadg.com\/en-us\/product\/category\/infectious-substances-packaging\/category-b-un3373\/\" target=\"_blank\" rel=\"noopener\"><strong>UN3373 compliant packaging<\/strong><\/a> or a complete <strong>UN3373 shipping kit USA<\/strong>, this guide outlines what is legally required.<\/p>\n<p>Unlike packaging for Category A Infectious Substances, packaging for Category B does not have to be UN approved, however, it does need to have demonstrated that it can pass certain performance tests.<\/p>\n<p>Under PI 650 or CFR 173.199, the packaging must consist of three components:<\/p>\n<ol>\n<li><strong>Primary receptacle<\/strong> (leakproof for liquids or siftproof for solids)<\/li>\n<li><a href=\"https:\/\/www.airseadg.com\/en-us\/product\/biobag-751-95kpa-specimen-bag\/\" target=\"_blank\" rel=\"noopener\"><strong>Secondary packaging<\/strong><\/a> (leakproof for liquids or siftproof for solids)<\/li>\n<li><a href=\"https:\/\/www.airseadg.com\/en-us\/product\/postal-pack-category-b-un3373-biological-substances\/\" target=\"_blank\" rel=\"noopener\"><strong>Rigid outer packaging<\/strong><\/a><\/li>\n<\/ol>\n<p>This structure forms a compliant <strong>UN3373 triple packaging system<\/strong>.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-8764\" src=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/Code-760-Postal-Pack-with-751-new-bag-LR-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/Code-760-Postal-Pack-with-751-new-bag-LR-300x300.jpg 300w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/Code-760-Postal-Pack-with-751-new-bag-LR-1024x1024.jpg 1024w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/Code-760-Postal-Pack-with-751-new-bag-LR-150x150.jpg 150w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/Code-760-Postal-Pack-with-751-new-bag-LR-768x768.jpg 768w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/Code-760-Postal-Pack-with-751-new-bag-LR-1536x1536.jpg 1536w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/Code-760-Postal-Pack-with-751-new-bag-LR-2048x2048.jpg 2048w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/Code-760-Postal-Pack-with-751-new-bag-LR-1800x1800.jpg 1800w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/Code-760-Postal-Pack-with-751-new-bag-LR-700x700.jpg 700w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><strong>Primary Receptacles: Key Requirements<\/strong><\/p>\n<p>Primary receptacles must be:<\/p>\n<ul>\n<li>Leakproof for liquids<\/li>\n<li>Siftproof for solids<\/li>\n<\/ul>\n<p>They must be packed so that, under normal transport conditions, they cannot break or leak into the secondary packaging.<\/p>\n<p>When multiple fragile primary receptacles are placed in one secondary package:<\/p>\n<ul>\n<li>Each receptacle must be individually wrapped or separated to prevent contact<\/li>\n<li>If liquids are present, sufficient absorbent material must be placed inside the secondary packaging<\/li>\n<li>The absorbent material must be capable of absorbing the entire contents of the primary receptacles<\/li>\n<\/ul>\n<p><strong>Secondary Packaging: Key Requirements<\/strong><\/p>\n<p>Secondary packaging must be:<\/p>\n<ul>\n<li>Leakproof for liquids<\/li>\n<li>Siftproof for solids<\/li>\n<li>Primary or secondary packaging must be 95 kPa capable for liquids shipped under P650<\/li>\n<\/ul>\n<p>Common examples include <a href=\"https:\/\/www.airseadg.com\/en-us\/product\/category\/infectious-substances-packaging\/95kpa-bags\/\"><strong>95kPa biohazard bags<\/strong><\/a> or <strong>95kPa specimen transport bags<\/strong> used as compliant secondary packaging.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-8792\" src=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-300x300.jpg 300w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-1024x1024.jpg 1024w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-150x150.jpg 150w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-768x768.jpg 768w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-1536x1536.jpg 1536w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-2048x2048.jpg 2048w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-1800x1800.jpg 1800w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-700x700.jpg 700w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><strong>95 kPa Requirement<\/strong><\/p>\n<p>For liquid substances, either the primary receptacle or the secondary packaging must withstand an internal pressure of <strong>95 kPa (0.95 bar)<\/strong> without leakage.<\/p>\n<p>This requirement is particularly important for air transport and is a critical component of <strong>IATA P650 compliant packaging<\/strong>.<\/p>\n<p>Businesses looking to <a href=\"https:\/\/www.airseadg.com\/en-us\/product\/category\/infectious-substances-packaging\/95kpa-bags\/\"><strong>buy 95kPa biohazard bags<\/strong><\/a> should ensure the bags have been independently tested to meet this pressure requirement.<\/p>\n<p><strong>Outer Packaging Requirements<\/strong><\/p>\n<p>The outer packaging must:<\/p>\n<ul>\n<li>Be rigid<\/li>\n<li>Have a minimum dimension of <strong>100 mm \u00d7 100 mm (3.9 in \u00d7 3.9 in)<\/strong> on at least one surface<\/li>\n<li>Include an itemized list of contents placed between the secondary and outer packaging<\/li>\n<li>Successfully withstand a <strong>1.2 meter drop test<\/strong> without leakage<\/li>\n<\/ul>\n<p><strong>Marking Requirements<\/strong><\/p>\n<p>The package must display:<\/p>\n<ul>\n<li>The <strong>UN3373 mark<\/strong>, set at a 45-degree angle (diamond-shaped), with a minimum side length of 50 mm<\/li>\n<li>The text <strong>\u201cBIOLOGICAL SUBSTANCE, CATEGORY B\u201d<\/strong> in letters at least 6 mm high<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-8803\" src=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/UN3373-packaging-requirements-USA-20-02-26-300x298.jpg\" alt=\"\" width=\"441\" height=\"438\" srcset=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/UN3373-packaging-requirements-USA-20-02-26-300x298.jpg 300w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/UN3373-packaging-requirements-USA-20-02-26-150x150.jpg 150w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/UN3373-packaging-requirements-USA-20-02-26.jpg 687w\" sizes=\"auto, (max-width: 441px) 100vw, 441px\" \/><\/p>\n<p><strong>Dry Ice<\/strong><\/p>\n<p>If Dry Ice is used, it must be placed:<\/p>\n<ul>\n<li>Outside the secondary packaging<\/li>\n<li>In the outer packaging<\/li>\n<li>Or within an overpack<\/li>\n<\/ul>\n<p>These requirements apply whether shipping domestically within the U.S. or internationally.<\/p>\n<p><strong>Summary: What Is Required to Ship UN3373 Legally?<\/strong><\/p>\n<p>To legally ship UN3373 substances, you must use a <strong>UN3373 compliant triple packaging system<\/strong> that includes:<\/p>\n<ul>\n<li>Leakproof or siftproof primary and secondary containers<\/li>\n<li>One layer (primary or secondary) capable of withstanding 95 kPa pressure for liquids shipped via P650<\/li>\n<li>Sufficient cushioning and absorbent material (for liquids)<\/li>\n<li>Outer packaging capable of passing a 1.2 meter drop test<\/li>\n<li>Proper UN3373 diamond marking and Category B identification text<\/li>\n<\/ul>\n<p>Failure to meet any of these requirements can result in rejected shipments and regulatory non-compliance.<\/p>\n<p><strong>Looking for UN3373 Compliant Packaging in the USA?<\/strong><\/p>\n<p>If your laboratory, hospital, diagnostic facility, or biotech company needs <strong>UN3373 compliant packaging<\/strong>, we offer:<\/p>\n<ul>\n<li><a href=\"https:\/\/www.airseadg.com\/en-us\/product\/biobag-752-95kpa-specimen-bag\/\" target=\"_blank\" rel=\"noopener\"><strong>95kPa specimen transport bags<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/www.airseadg.com\/en-us\/packaging-guidance\/new-95kpa-biohazard-bags-for-un3373-specimen-shipping\/\" target=\"_blank\" rel=\"noopener\"><strong>95kPa biohazard bags tested to PI 650 requirements<\/strong><\/a><\/li>\n<li>Complete <a href=\"https:\/\/www.airseadg.com\/en-us\/product\/bioshipper-2-complete-kit-for-un3373\/\" target=\"_blank\" rel=\"noopener\"><strong>UN3373 shipping kit USA solutions<\/strong><\/a><\/li>\n<li><strong>Bulk UN3373 packaging kits<\/strong> for high-volume operations<\/li>\n<li><a href=\"https:\/\/www.airseadg.com\/en-us\/product\/biotransporter-3l-un-combination-packaging-4h2\/\" target=\"_blank\" rel=\"noopener\">Temperature control packaging for temperature regulated UN 3373 shipments<\/a><\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-674\" src=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/biotransporter-approved-items-dangerous-goods-300x297.png\" alt=\"Infectious substance packaging\" width=\"300\" height=\"297\" srcset=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/biotransporter-approved-items-dangerous-goods-300x297.png 300w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/biotransporter-approved-items-dangerous-goods-150x150.png 150w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/biotransporter-approved-items-dangerous-goods-768x761.png 768w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/biotransporter-approved-items-dangerous-goods-1024x1015.png 1024w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/biotransporter-approved-items-dangerous-goods-1800x1783.png 1800w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Whether you need to order individual <strong>95kPa biohazard bags<\/strong> or purchase a complete <strong>Category B shipping kit<\/strong>, our solutions are designed to meet PI 650 and CFR 173.199 requirements.<\/p>\n<p><strong>Learn More About UN3373 &amp; 95kPa Packaging Requirements<\/strong><\/p>\n<p>We provide educational resources to help businesses understand infectious substance shipping regulations, including:<\/p>\n<ul>\n<li><a href=\"https:\/\/www.airseadg.com\/en-us\/infectious-substances-category-a-category-b-packaging-explained\/\" target=\"_blank\" rel=\"noopener\">Detailed guides on UN3373, UN2814, and UN2900 packaging requirements<\/a><\/li>\n<li><a href=\"https:\/\/www.airseadg.com\/en-us\/packaging-guidance\/are-your-biohazard-bags-truly-95kpa-capable\/\" target=\"_blank\" rel=\"noopener\">Information explaining what 95 kPa bags are and why they are required<\/a><\/li>\n<li><a href=\"https:\/\/youtu.be\/yUzaXEOuR_8\" target=\"_blank\" rel=\"noopener\">Demonstration videos of 95 kPa pressure testing<\/a><\/li>\n<\/ul>\n<p>For more information about our <a href=\"https:\/\/www.airseadg.com\/en-us\/product\/category\/infectious-substances-packaging\/category-b-un3373\/\" target=\"_blank\" rel=\"noopener\"><strong>UN3373 compliant packaging solutions<\/strong><\/a>, or to request pricing on <strong><a href=\"https:\/\/www.airseadg.com\/en-us\/product\/category\/infectious-substances-packaging\/95kpa-bags\/\" target=\"_blank\" rel=\"noopener\">95kPa biohazard bags<\/a> and UN3373 shipping kits<\/strong>, <a href=\"https:\/\/www.airseadg.com\/en-us\/contact\/\" target=\"_blank\" rel=\"noopener\">contact our team today.<\/a><\/p>\n<p><em><strong>Information correct at time of publication. Published Date 20 Feb 2026<\/strong><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Do you ship UN3373? If your organization ships UN3373 Biological Substance, Category B materials in the United States, understanding the legal packaging requirements is essential. Below is a summary guide to the key requirements under Packing Instruction PI 650 and CFR173.199. For companies looking to purchase UN3373 compliant packaging or a complete UN3373 shipping kit [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":8803,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"editor_notices":[],"footnotes":""},"categories":[1337],"tags":[],"class_list":["post-8807","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-packaging-guidance"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What Are the Key Packaging Requirements for UN3373 Substances Under PI 650? | Air Sea USA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.airseadg.com\/en-us\/packaging-guidance\/what-are-the-key-packaging-requirements-for-un3373-substances-under-pi-650\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What Are the Key Packaging Requirements for UN3373 Substances Under PI 650? | Air Sea USA\" \/>\n<meta property=\"og:description\" content=\"Do you ship UN3373? If your organization ships UN3373 Biological Substance, Category B materials in the United States, understanding the legal packaging requirements is essential. Below is a summary guide to the key requirements under Packing Instruction PI 650 and CFR173.199. 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