{"id":8641,"date":"2025-06-20T09:24:58","date_gmt":"2025-06-20T13:24:58","guid":{"rendered":"https:\/\/www.airseadg.com\/en-us\/?p=8641"},"modified":"2026-04-28T03:52:48","modified_gmt":"2026-04-28T07:52:48","slug":"what-is-un3373-and-what-are-the-packaging-requirements","status":"publish","type":"post","link":"https:\/\/www.airseadg.com\/en-us\/packaging-guidance\/what-is-un3373-and-what-are-the-packaging-requirements\/","title":{"rendered":"What is UN3373 and what are the packaging requirements?"},"content":{"rendered":"<p>The safe and compliant transport of infectious substances is critical to protecting human and animal health. Among these substances, <strong>UN 3373<\/strong> refers specifically to <strong>Biological Substance, Category B<\/strong>, a classification under Class 6.2 Infectious Substances. Unlike Category A substances, which pose a high risk causing permanent disability, life threatening or fatal disease in otherwise healthy humans or animals, Category B includes substances that are <strong>not capable of causing life-threatening or fatal diseases<\/strong> during transport but still require strict handling and packaging protocols in line with UN dangerous goods transport regulations.<\/p>\n<h2>Understanding UN 3373<\/h2>\n<p><strong>UN 3373<\/strong> applies to infectious substances that do <strong>not meet the criteria for Category A<\/strong>. These are typically clinical samples or diagnostic specimens that may contain pathogens but are not identified as Category A substances. Even though they pose a lower risk, improper handling can still result in exposure or contamination, making correct packaging essential.<\/p>\n<h2>Why Is Compliant Packaging for UN 3373 Important?<\/h2>\n<p>Infectious substance packaging plays a vital role in <strong>preventing leakage and accidental exposure<\/strong> during transport. If the primary receptacle fails, the packaging must contain the substance and protect anyone who comes into contact with the shipment, including couriers, lab workers, and customs agents. <a href=\"https:\/\/www.airseadg.com\/en-us\/product\/category\/infectious-substances-packaging\/category-b-un3373\/\" target=\"_blank\" rel=\"noopener\">Packaging for UN 3373<\/a> ensures that the biological substance is securely enclosed, even if subjected to rough handling or environmental conditions during shipping.<\/p>\n<h2>Packaging Requirements for UN 3373<\/h2>\n<p>Shipments classified under UN 3373 must adhere to <strong>Packing Instruction P650<\/strong>, which outlines the packaging requirements for <strong>Category\u00a0B infectious substances<\/strong>. These requirements include the <strong>triple packaging system<\/strong>, designed to ensure containment and prevent leakage, although packaging featuring an UN specification mark is not required for Cat B substances, packaging capable of the performance test criteria is:<\/p>\n<ol>\n<li><strong>Primary Receptacle<\/strong>\n<ul>\n<li>Holds the actual specimen or substance<\/li>\n<li><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-8792 alignright\" src=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-300x300.jpg 300w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-1024x1024.jpg 1024w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-150x150.jpg 150w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-768x768.jpg 768w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-1536x1536.jpg 1536w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-2048x2048.jpg 2048w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-1800x1800.jpg 1800w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/BioBag-751-and-752-LR-700x700.jpg 700w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Must be leakproof\/Siftproof<\/li>\n<li>If there are multiple primary receptacles, each must be individually wrapped or cushioned<\/li>\n<\/ul>\n<\/li>\n<li><a href=\"https:\/\/www.airseadg.com\/en-us\/product\/biobag-751-95kpa-specimen-bag\/\" target=\"_blank\" rel=\"noopener\"><strong>Secondary Packaging<\/strong><\/a>\n<ul>\n<li>Also, leakproof\/siftproof for either the primary of secondary packaging<\/li>\n<li>The primary of secondary packaging<a href=\"https:\/\/www.airseadg.com\/en-us\/packaging-guidance\/are-your-biohazard-bags-truly-95kpa-capable\/\" target=\"_blank\" rel=\"noopener\"> <strong>must meet 95kPa pressure test <\/strong><\/a>(for liquids\/IATA)<\/li>\n<li>Must contain <strong>enough absorbent material<\/strong> to absorb the entire contents of the primary receptacle in case of breakage or leakage (liquids)<\/li>\n<\/ul>\n<\/li>\n<li><a href=\"https:\/\/www.airseadg.com\/en-us\/product\/postal-pack-category-b-un3373-biological-substances\/\" target=\"_blank\" rel=\"noopener\"><strong>Outer Packaging<\/strong><\/a>\n<ul>\n<li>Must be <strong>rigid<\/strong>, but does <strong>not require UN approval<\/strong> (unlike Category A packaging)<\/li>\n<li>Must be clearly marked with the <strong>UN 3373 diamond-shaped label<\/strong> and &#8220;Biological Substance, Category B&#8221;<\/li>\n<li>Packaging for Category B does not have to be UN approved, however, it does need to have demonstrated that it can pass certain performance tests.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p>Unlike <a href=\"https:\/\/www.airseadg.com\/en-us\/product\/category\/infectious-substances-packaging\/category-a\/\">packaging for Category A<\/a>, <strong>UN 3373 compliant packaging does not require UN certification<\/strong> (carry a UN specification mark) but must still demonstrate the ability to withstand performance testing, such as 1.2 Metre drop tests and <a href=\"https:\/\/youtu.be\/yUzaXEOuR_8\" target=\"_blank\" rel=\"noopener\">pressure tests<\/a> where required. It&#8217;s critical that the packaging is assembled exactly as instructed by the manufacturer to ensure compliance and safety.<\/p>\n<p><strong>This table summarises the packaging requirements in P650\/CFR 173.199.<\/strong><\/p>\n<p>Shippers must refer to P650 (IATA &amp; IMDG) or CFR 173.199 for full provisions.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-8803\" src=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/UN3373-packaging-requirements-USA-20-02-26-300x298.jpg\" alt=\"\" width=\"503\" height=\"499\" srcset=\"https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/UN3373-packaging-requirements-USA-20-02-26-300x298.jpg 300w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/UN3373-packaging-requirements-USA-20-02-26-150x150.jpg 150w, https:\/\/www.airseadg.com\/en-us\/wp-content\/uploads\/sites\/2\/UN3373-packaging-requirements-USA-20-02-26.jpg 687w\" sizes=\"auto, (max-width: 503px) 100vw, 503px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2>Additional Considerations<\/h2>\n<ul>\n<li><strong>Category B substances may be shipped in UN approved Category A packaging<\/strong>, though this is not required.<\/li>\n<li>Conversely, <strong>Category A substances must never be transported in Category B packaging<\/strong>.<\/li>\n<li>Always confirm with your packaging supplier that the packaging used meets the <strong>relevant testing standards<\/strong> for UN 3373 shipments.<\/li>\n<\/ul>\n<h2>How to ensure you assembly correctly and compliantly<\/h2>\n<p>At Air Sea USA we provide assembly instructions for all our combination packaging, to help shippers assemble the packaging correctly and compliantly, you can find our assembly instructions for our <a href=\"https:\/\/www.airseadg.com\/product-assembly\/code-760\/\" target=\"_blank\" rel=\"noopener\">postal pack<\/a> and larger <a href=\"https:\/\/www.airseadg.com\/product-assembly\/code-761\/\" target=\"_blank\" rel=\"noopener\">bioshipper 1<\/a> here. if your UN 3373\u00a0 substance is temperature sensitive you can use our <a href=\"https:\/\/www.airseadg.com\/en-us\/product\/category\/infectious-substances-packaging\/category-b-un3373\/\" target=\"_blank\" rel=\"noopener\">temperature control packaging<\/a> specifically made to carry infectious substances.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-10557\" src=\"https:\/\/www.airseadg.com\/wp-content\/uploads\/CAT-B-Group-Shot-2-Low-Res-300x300.jpg\" alt=\"Category B Infectious Substance Packaging\" width=\"300\" height=\"300\" \/><\/p>\n<h2>Conclusion<\/h2>\n<p>Transporting biological substances under UN 3373 comes with specific packaging requirements. By following <strong>Packing Instruction P650\/ CFR 173.199 <\/strong>and ensuring that triple-layer packaging is used and assembled correctly, shippers can minimize risks and maintain regulatory compliance. While the requirements are less stringent than those for Category A substances, the importance of <strong>safety, accuracy, and adherence to instructions<\/strong> cannot be overstated.<\/p>\n<p><strong>If you are unsure about which packaging is appropriate for your Cat B biological samples, <a href=\"https:\/\/www.airseadg.com\/en-us\/contact\/\" target=\"_blank\" rel=\"noopener\">contact us<\/a> we are happy to help.<\/strong><\/p>\n<p>Interested in shipping Category A substances read our how to <a href=\"https:\/\/www.airseadg.com\/en-us\/infectious-substances-category-a-category-b-packaging-explained\/\" target=\"_blank\" rel=\"noopener\">ship infectious substances article here<\/a>.<\/p>\n<p><strong><em>Information correct at the time of publication 20\/06\/25. Last Updates 20\/02\/26<\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The safe and compliant transport of infectious substances is critical to protecting human and animal health. Among these substances, UN 3373 refers specifically to Biological Substance, Category B, a classification under Class 6.2 Infectious Substances. Unlike Category A substances, which pose a high risk causing permanent disability, life threatening or fatal disease in otherwise healthy [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":8599,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"editor_notices":[],"footnotes":""},"categories":[1337],"tags":[],"class_list":["post-8641","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-packaging-guidance"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is UN3373 and what are the packaging requirements? | Air Sea USA<\/title>\n<meta name=\"description\" content=\"What is UN 3373? 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